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Bioreactor Scale-Up and CFD Review 12/3/10 ROB LEVINE * What is Scale-Up? To take a manufacturing process from the laboratory scale to a desired large scale at which ...
ENCH 482 Bioreactor Scale-Up and CFD Industrial Lecture Series #5 December 3rd, 2010 * Drawbacks of CFD Need CAD experience – develop the model Need the meshing ...
Designing a bioreactor: The coupled set of mass balance equations which describe the ... possible to decrease the volume of gas per volume of liquid per minute on scale-up ...

External heat exchanger unit is independent of the reactor, easy to scale up, and ... Chapter VII Introduction Two types of common heat transfer application in bioreactor ...
For scale-up suspension culture is grown in Bioreactor and large-scale production of plant derived secondary metabolite is facilitated. Advantages of producing compounds ...
Bioreactor size - to provide required production capacity 2. Mass transfer - to ... Effect on other unit operations (b) Economics (c) Potential for scale-up Types of ...
Measurement of Bioreactor KLa Motivations 2. Good example of mass transfer at gas ... Chemical Engineers Process Engineering Validation Management Pilot testing Scale-up ...
provide the appropriate shear conditions required for the breaking up of ... Sodium carbonate is also commonly used in small scale bioreactor systems.
Workshop on Industrial scale cultivation of cells in pharmaceutical or antibody ... of the product of interest Single harvest Smaller harvest volume Larger bioreactor (up ...
Bioreactor technology Culture Strategies Strategy 2: microcarriers Day 1 Day 3 125 mL ... PSCs expansion more efficiently PSC Expansion in Bioreactors improve and up scale ...
Process development Scientists and engineers begin to figure out how to “scale up ... bottles) As the cells grow and multiply, they are introduced into a small bioreactor.
... Chlorella strains and species in cold storage Photobioreactor Design Scale Up ... tanks at ERLab, Tucson Raceways in Jeddah, Saudi Arabia with Chlorella Bioreactor with ...
Factors related to bioreactor operation Product yield Annual demand for product ... Consider constraints in terms of scale-up conditions List the available substrates ...
1999: Pilot-Scale demonstration study was completed ... could also be degraded using an immobilized cell bioreactor ... to the normally fresh-water bacteria that make-up the ...
Photo Bubble Bioreactor BIOMAN 2012 BIOMAN 2012 in San Diego Biohydrogen from Bacteria ... Validation of Sterilization 4 Upstream Processing : Cell Culture, Scale-Up ...
Traditional Mammalian Cell Culture Scale up problematic. Animal Cell Bioreactors ... be selected for their ability to grow in the higher shear environment of a bioreactor.
... Up to 98% removal 1 gpm pilot to be built June 2008 Full Scale unit costs: $0.26 per 1000 gallons or $115 per kg Selenium Design similar to sulfate reducing bioreactor ...
... substance (crude) Drug substance (pure) Drug product - (sterile) Formulation/ Filling Cell line manufacture Medium development Bioreactor process development & scale-up ...
... Process Optimisation & Contour Mapping Modelling & Process Characterisation Verification & Transfer model confirmation Bioreactor simulation & identification Scale - up ...
LIFE CYCLE ASSESSMENT OF A BIOREACTOR AND AN ENGINEERED ... ODP) Global g CO2 eq. Global warming (GWP) Scale ... Union (EU) emission inventory programme, set up by ...
... Analytes Pilot Study Schedule Construction Start Dec 99 System Start-up Feb ... drinking water in the San Gabriel Basin Pilot Study Design GAC/FB Bioreactor (Full Scale Plant ...
And scale can definitely be a factor, especially as product scale-up occurs early in ... Case Study #2 Bioreactor SterilityFocused Assessments. Equipment. Operations
Construct a lab-scale bioreactor. Establish optimal operating parameters for the lab ... (M3) Scale up cultivation of algae to a large scale. Analyze algae composition and ...
... Greifswald Cofounder of BioSilta (2008), Scanbec (2000) EnBase principle of fed-batch cultivation in small scale Set up and validation of a novel scale down bioreactor ...
... process and waste utilization Batch fermentation: Optimization process: pH, substrate concentration, Nutrient supplementation Up-scale production: Bioreactor ...

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