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Recent Developments In New Oral Anticoagulants Eric Watts Basildon Hospital Background - AF Warfarin is effective, 2/3 risk reduction for CVA Better than maximal ...
... to be approved as new oral anticoagulants in the near future The future for anticoagulants Factor Xa is an attractive target for the design of new oral anticoagulants ...
K dependent Factors Affected by Oral Anticoagulants Anticoagulant drugs to treat thromboembolism Drug Class Prototype Action Effect Anticoagulant Parenteral Heparin ...

K dependent Factors Affected by Oral Anticoagulants Thrombi Acc to location & composition Arterial Occur in areas of rapid flow (arteries) In response to an injured or ...
ORAL DIRECT THROMBIN INHIBITORS Girish C & M Jayanthi Dept of Pharmacology ... Mandatory lab monitoring Drug interactions Why new oral anticoagulants ?
... plaque to prevent rethrombosis Reopro cont. Used with aspirin and heparin and is contraindicated in clients who have recently received oral anticoagulants or IV dextran.
Oral Anticoagulants in the Pipeline. Tracy Sprunger, Pharm.D., BCPS. Assistant Professor, Pharmacy Practice. Butler College of Pharmacy and Health Sciences
PT prolonged PTT prolonged Functional assays of vitamin K factors show low level Acquired coagulation disorders Vitamin K Antagonists Oral anticoagulants ...
Common anticoagulants encountered in the surgical setting. Antiplatelet medications. Oral anticoagulants. Standard Heparin. Herbal preparations. New anticoagulants
... Lupus-anticoagulant Malignancy Oral contraceptives Post-op and trauma Myeloproliferative disorders Therapies Heparin Monitor with APTT LMWH no HIT Oral anticoagulants (e ...
K dependent Factors Affected by Oral Anticoagulants Coumarins act here Coumarins act here Vitamin K Coumarins are competitive inhibitors Oral anticoagulants – 4 ...
... Objective 1: identify general reasons anticoagulants are given * Objective 2: identify the ... Caution: antiplatelet or warfarin therapy * Warfarin (Coumarin) 1st oral ...
The risk of significant bleeding in patients on oral anticoagulants and with a stable INR in the therapeutic range 2-4 (i.e.
Functional Assays of Lupus Anticoagulants aPTT Some manufacturers offer aPTT ... patients with LA will have a normal PT unless they are receiving oral anticoagulants or ...
... stays ANTICOAGULANT THERAPY Focus on venous thromboembolism (VTE) Focus on parenteral therapy Not topics for discussion today: Thrombolytic therapy Oral anticoagulants ...
New Anticoagulants: Beyond Warfarin and Heparin Rachel LaCount Resident in Pathology ... II, VII, IX, X Vit K = cofactor Warfarin blocks the reduction of Vit K Oral ...
... 75 mg once daily), aspirin/ extended-release dipyridamole (25 mg/200 mg bid), or cilostazol (100 mg bid) over no antiplatelet therapy (Grade 1A), oral anticoagulants ...
... Drugs Methimazole and propyithiouracil (PTU) Side effects/adverse effects Liver and bone marrow toxicity Interactions Increased activity of oral anticoagulants Additive ...
... calculated by body weight Q daily or Q12Hrly SC administration No Laboratory monitoring necessary Exceptions - children, obesity, renal failure Oral Anticoagulants ...
... to aid treatment compliance and avoid the serious consequences of thrombosis and bleeding Requirements of new prophylactic agents Key features of new oral anticoagulants ...
... vitamin K injection at birth Coagulation tests: Prolongation of PT and APTT, normal TT Conventional model of coagulation Vitamin K antagonism Oral anticoagulants ...
Lupus Anticoagulants Antiphospholipid antibodies (APA) are directed against ... abortion or thrombotic events Monitor anticoagulant therapy Oral anticoagulants ...
... sites then lodge  in lung (capillary level)  inadequate O2 & CO2 exchange occur (ie. pulmonary embolism & cerebral embolism) Oral & parenteral anticoagulants ...
Objectives Review the mechanisms of action between oral and parenteral ... and applications: Development of clinical guidelines for management of oral anticoagulants ...
... This chapter addresses the many general management questions related to anticoagulants ... VKAs with INRs > 10.0 and with no evidence of bleeding, we suggest that oral ...

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