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Aminoglycosides Intro Group of antibiotics used in the treatment of bacteria infections aerobic G-ve Consists of 2 or more amino sugars and a hexose nucleus Serious ...
... or worsen renal failure Macrolides are generally safe Aminoglycosides are contraindicated in severe renal impairment Antimicrobials and Older Adults Aminoglycosides can ...
... less affected, once daily dosing Aminoglycosides Cochlear toxicity Outer hair cell loss first in basal turn then to apex Inner hair cell loss later Aminoglycosides ...

... Macrolides/Azalides/Lincosamides Aminoglycosides Fluoroquinolones Oxazolidinones Antibiotic brands 50 penicillins 71 cephalosporins 12 tetracyclines 8 aminoglycosides 1 ...
Drug Time to steady state Sampling time Therapeutic range (mg/L) Aminoglycosides Amikacin Adults (< 30 y): ~ 2.5-15 h Peak 0.5 ...
Lower activity against gram positives Often used with aminoglycosides when treating pseudomonal infections. Resistance Mechanisms B-lactamase – hydrolyze the B-lactam ...
... Kanamycin Neomycin Streptomycin amikin Aminoglycosides Poor oral absorption No oral forms, only IV TOXICITY cautions Nephro oto Bactericidal action Aminoglycosides ...
... does not occur C. narrow margin between therapeutic and toxic levels D. nephrotoxicity E. Ototoxicity Which one of the following are/is characteristic of Aminoglycosides ...
... Resistant TB Tuberculosis Modify treatment plan according to Weight Hepatic function Hepatotoxic: isoniazid, rifampin Renal function Nephrotoxic: aminoglycosides Dose ...
... tables Base on measured loses Calculate maintenance dose multiplication factor (MDMF) Dosage Adjustments in CRRT Frequent blood level determinations Aminoglycosides ...
The Aminoglycosides include Streptomycin, Gentamicin, Tobramycin, and Amikacin (all parenteral), as well as Neomycin (topical, oral). Aminoglycosides Streptomycin ...
The Aminoglycosides The following are the aminoglycosides 1. Gentamycin 2. Tobramycin 3. Amikacin 4. Netilmicin 5. Kanamycin The Aminoglycosides Mechanism of action ...
The antibiotics used most commonly are aminoglycosides (25%) or vancomycin (14%) alone, but more commonly these are used in combination (60%). Adverse reactions due to ...
Antibiotic Prophylaxis In Elective Hysterectomy Prof.Surendra Nath Panda & Dr. Vanita Panda Dept. Of Obst. & Gynaec. M. K.C.G. Medical College Berhampur - 760004 ...
Aminoglycosides (cont.) Examples Tobramycin: used for pseudomonas and for some gentamicin-resistant organisms. Some aminoglycosides,e.g. Gentamicin, may also be applied ...
... for hi-risk) Higher mortality associated with delayed treatment; aminoglycosides are drugs of choice Higher mortality associated with delayed treatment; aminoglycosides ...
... on receptors Change in pharmacodynamics than pharmacokinetics Longer acting NMB agents affected more Non-depolarizing agents Altered response Antibiotics Aminoglycosides ...
All aminoglycosides cross the placental barrier and may accumulate in fetal plasma and amniotic fluid. Metabolism of the aminoglycosides does not occur in the host.
many authorities recommend early surgery for left-sided Pseudomonas endocarditis High-dose regimens of antipseudomonal penicillins combined with aminoglycosides are used ...
According to spectrum 1- Narrow spectrum as penicillins ,aminoglycosides 2- Broad spectrum as tetracyclines , chloramphenicol REASONS FOR FAILURE OF CHEMOTHERAPY . 1 ...
Patterns of Microbial Killing Concentration dependent Higher concentration greater killing Aminoglycosides, Flouroquinolones, Ketolides, metronidazole, Ampho B ...
... Class based on chemical structure of the compounds Drugs need to enter bacteria => entry inhibition is a point of drug resistance Classification: Aminoglycosides ...
... AUC:MIC90 RATIO HALF LIFE OF DRUG TIME ABOVE THE MIC CONCENTRATION DEPENDENT KILLING Greater cidal activity with higher concen (e.g. aminoglycosides, b ...
Mechanisms of Action There are also other mechanisms: The tetracyclines compete with incoming transfer-RNA molecules; the aminoglycosides cause the genetic message to be ...
Aminoglycosides: Toxicities Serious toxicities: caution Nephrotoxicity Ototoxicity Block neuromuscular action, which can lead to respiratory paralysis Monitor drug levels ...

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